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As oxidative stress increases, glutathione is used as an antioxidant, and active GSH gets depleted
Much of the published research exists in animal models, case studies, and small pilot studies
Tastan B, Arioz BI, Genc S (2022) Targeting NLRP3 inflammasome with Nrf2 inducers in central nervous system disorders
Key Takeaways There is no official contraindication: Eli Lilly's prescribing information for Mounjaro and Zepbound does not list alcohol as a contraindication or drug interaction Alcohol worsens tirzepatide's GI side effects: Nausea, vomiting, and acid reflux already common on tirzepatide get significantly worse with alcohol Hypoglycemia risk increases: Both tirzepatide and alcohol independently lower blood sugar, creating a compounding risk especially for diabetic patients Alcohol slows weight loss: Empty calories, impaired fat metabolism, and increased appetite undermine the reason most people take tirzepatide Many patients report reduced alcohol cravings: GLP-1 receptor agonists appear to reduce the rewarding effects of alcohol in emerging research "Can you drink alcohol on tirzepatide?" is one of the first questions people ask after starting Mounjaro or Zepbound
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