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The incretin system: glucagon-like peptide-1 receptor agonists and dipeptidyl peptidase-4 inhibitors in type 2 diabetes
For injectable GLP-1 medications, diarrhoea generally does not significantly impact absorption since
The most widely used ones right now are semaglutide (sold as Ozempic for diabetes management and Wegovy for weight loss) and tirzepatide, which targets both GLP-1 and a second hormone called GIP (Mounjaro for diabetes, Zepbound for weight loss)
1,2 By specifically binding to the key hormone GLP-1, it regulates blood glucose levels and lipid metabolism
For those planning pregnancy, specific washout periods apply (e.g., discontinue semaglutide at least 2 months before planned conception)