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For example: Persistent fatigue and low energy on Lexapro alone Continued anxiety symptoms with Wellbutrin alone Sexual side effects from SSRI treatment Complementary Symptom Targeting The combination can address different aspects of depression simultaneously: Lexapro targets mood regulation and anxiety Wellbutrin addresses energy, motivation, and cognitive symptoms How the Combination Works When prescribed together, Lexapro and Wellbutrin target three major neurotransmitter systems simultaneously: Serotonin (from Lexapro): Helps with mood stability, anxiety reduction, and emotional regulation Dopamine and Norepinephrine (from Wellbutrin): Support energy levels, motivation, focus, and pleasure response This multi-target approach can be particularly beneficial for people whose depression involves both emotional symptoms (sadness, anxiety) and motivational symptoms (low energy, lack of interest) [4]

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