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Both are not approved for human or veterinary use

In cardiovascular research, fluid retention and metabolic changes linked to these peptides may complicate studies involving heart failure or severe hypertension

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(8) S Wrigley, D Arafa, and D Tropea (2017) Insulin-Like Growth Factor 1: At the Crossroads of Brain Development and Aging Frontiers in Cellular Neuroscience, 2017 Feb 1, Volume 11, Page 14

At a volume fraction of 50 L/mL, CAT activity recovered to 66.69% 1.72% and 51.60% 1.86% of that of the control group, respectively