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The article explains that GLP-1 receptor agonists alter normal gut motility and fluid balance, and that in some patients the result is accelerated colonic transit further down the tract

Category 1 status only means a substance is eligible for use by 503A compounding pharmacies pending final FDA rulemaking

GLP-1 Side Effects: Joint Pain Causes and Management GLP-1 receptor agonists, including semaglutide (Ozempic, Wegovy), dulaglutide (Trulicity), and liraglutide (Victoza, Saxenda), are widely prescribed in the UK for type 2 diabetes and weight management

However, clinical observations and trial data have identified specific circumstances where these drugs may be associated with worsening diabetic retinopathy, particularly in patients with pre-existing retinal disease