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Available at: [accessed March 2026]. vvSELECT Trial: Semaglutide and cardiovascular outcomes in obesity without diabetes

To put this into perspective, imagine a woman who weighs 200 pounds

When this receptor is activated, it sends signals that: Increase insulin release when blood sugar rises (NIH) Reduce glucagon, a hormone that raises blood sugar (NIH) Slow down stomach emptying (NIH) Communicate fullness to the brain (NIH) In simple terms, GLP-1 helps your body decide how much energy to use, store, or stop consuming

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When I work with patients to encourage weight loss, I first consider any underlying disease processes we need to reduce: A patient with mild hypertension may respond favorably to a 5% weight loss, or even slightly less

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