Others choose lower concentrations (like 2.5 mg/mL) to allow more precise measurement of small doses
In patients with obesity (mean age 51.3 years, 65.6% women), semaglutide compared with non-GLP-1RA anti-obesity medications was associated with lower risk for incident CUD in patients with no prior history CUD (HR: 0.56, 95% CI: 0.420.75), and recurrent CUD diagnosis in patients with a prior history CUD (HR: 0.62, 95% CI: 0.460.84)
Dosing follows a slow titration: 0.25 mg weekly for four weeks, then 0.5 mg, 1 mg, 1.7 mg, and finally 2.4 mg at week 17 if tolerated
But there are a few things worth understanding before you assume its entirely straightforward
Eight-year weight losses with an intensive lifestyle intervention: the look AHEAD study
As you draw doses out, the headspace increases, exposing more of the solution surface to air and potential oxidation