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1 Institute for Clinical and Experimental Medicine, Prague, Czechia, 2 EDUMED s.r.o., Nchod, Czechia, 3 Internal and Diabetology Clinic, Valask Klobouky, Czechia, 4 Private Diabetology Clinic, Krnov, Czechia, 5 Diaclinic s.r.o, esk Budjovice, Czechia, 6 First Faculty of Medicine, Charles University, Prague, Czechia