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This equilibrium is particularly critical in high-energy-demand tissues, such as the heart, where copper serves as an indispensable cofactor for key metabolic enzymes and mitochondrial function [18, 19]

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The NO levels were significantly higher in children, adolescents and adults [117,123] and also significant increases in NO synthase activity were observed in children and adolescents with ADHD [124]

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Within this process, First-in-Human (FIH) trials represent one of the most important transitions in the development of a new medicine