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2.3 Discontinuation of QSYMIA 15 mg/92 mg Discontinue QSYMIA 15 mg/92 mg gradually by taking QSYMIA 15 mg/92 mg orally once daily every other day for at least 1 week prior to stopping treatment altogether, due to the possibility of precipitating a seizure [see Warnings and Precautions (5.9) and Drug Abuse and Dependence (9.3)]

Microglia become hypofunctional and release metalloproteases and tau seeds when phagocytosing live neurons with P301S tau aggregates

Elevated heart rate and blood pressure place additional strain on the heart

The indirect concerns described above are real but manageable with the right approach and the right provider

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Vitamin C and Vitamin B12 Taking high doses of vitamin B12 and vitamin C together can reduce vitamin B12 availability