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The absorption rate depends on the formulation vehicle, the hold time, the concentration, and individual anatomy

While slightly less effective at inducing weight loss than the Wegovy pill, trials have suggested that orforglipron could be used as a long-term weight maintenance option for those who have lost weight with GLP-1 injections

However, individual tolerance varies

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Common side effects Nausea Vomiting Diarrhea or constipation Abdominal pain Headaches Contraindications Doctors generally advise caution or avoidance in patients with: A history of medullary thyroid cancer or MEN-2 syndrome Severe gastrointestinal disorders Certain pancreatic conditions There are also concerns about misuse, particularly in a culture influenced by celebrity body standards