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Conversely, brain IR, less recognized but equally important, pertains to impaired insulin signaling in neuronal and glial cells [6]

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This is not the same as tolerance

In this context, such effect biomarkers are recognized as an ideal tool for investigating the relationships between exposure to environmental chemical and adverse health outcomes in population-based studies, as well as for elucidating some of the mechanisms underlying these associations 6,10,24

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