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Neurotransmitter signaling and mental health (emerging evidence) Inositol is also involved in signaling pathways in the brain, including those related to serotonin and other neurotransmitters.20 This has led to research interest in psychiatric conditions such as panic disorder, obsessive-compulsive disorder, and depression.35 36 37 41 Small clinical trials have reported symptom improvements at relatively high doses (often 1218g per day), but results have been inconsistent, and large, well-controlled studies are lacking