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Optimal results typically appear after 3-6 months of regular application

EU approval typically follows FDA approval by 36 months

Patti AM, Al-Rasadi K, Katsiki N, et al

These data indicate that when normal men are given TE, serum IGF-I levels increase after six weeks of treatment

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That does not prove a human timeline, but it explains why gut-related use has been studied more than most other applications