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Because the drug can cause a transient elevation in blood pressure after dosing, patients with cardiovascular risk and those on antihypertensive therapy warrant particular attention, and uncontrolled hypertension is a reason not to use it

It also was protective after stroke in rats (Tadalafil, a long-acting type 5 phosphodiesterase isoenzyme inhibitor, improves neurological functional recovery in a rat model of embolic stroke - PubMed) improving neurological recovery (but without affecting the size of the injury area)

The initial identification of ChaC-like enzymes in plants occurred in a 2005 study on submergence-induced genes in rice, where the upregulated gene OsCTP was noted for its high similarity to the E

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Cole MA, Quan T, Voorhees JJ, et al