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In our current analysis of the STEP 1 data, we found evidence that semaglutide might lower CVD risk even in populations not enriched for multiple CVD risk factors or with established CVD (primary prevention)

Subsequent assay studies indicated that (R)-3-amino-1-(2-benzoyl-1,2-diazepan-1-yl)-4-(2,4,5-trifluorophenyl) butan-1-one (40) possesses strong in vitro activity, favorable selectivity, and in vivo efficacy in mouse models (Figure 6)

The two drugs are also competing head to head in obesity, where Novo Nordisk sells its drug as Wegovy and Lilly's is called Zepbound

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