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Moreover, periostin, which is primarily secreted by cardiac fibroblasts after myocardial infarction 88 , has been shown to induce cardiomyocyte cell cycle reentry and mitosis, and was associated with improved ventricular remodeling and myocardial function, reduced fibrosis and infarct size, and increased angiogenesis after myocardial infarction in mice 89

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Bottom-up and middle-down proteomics have comparable accuracies in defining histone post-translational modification relative abundance and stoichiometry