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NIH research review Found that KPV acts locally in the colon, minimizing systemic side effects seen in traditional IBD medications

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A randomized, double-blind clinical trial found that 1,000 mg of NAC taken twice daily (2,000 mg/day total) in addition to maintenance antipsychotic medications significantly improved scores on symptom scales and decreased akathisia (restlessness) compared to medications plus placebo [28]

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