Beta-Thalassemia/HbE patients with both UGT1A1*28 and UGT1A6*2 polymorphisms have not demonstrated a significant difference in pharmacokinetics of acetaminophen [23]
The resulting poor overlap with the functions of class I GRXs might be advantageous in evolutionary terms
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"But if you're somebody like McDonald's or Burger King, it's a very different story," he added