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6.3 Targeted bilirubin nanoparticles Tumors generate large amounts of ROS during rapid metabolic proliferation, which can promote tumor cell survival, invasion, proliferation, and metastasis by regulating various signaling pathways (223, 224)

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As a more general consideration, we continue to recognize there are ACOs that may need time to gain experience with the Shared Savings Program by participating in a one-sided model prior to transitioning to two-sided risk, which may be indicated by entry of some higher spending ACOs in the Shared Savings Program under a one-sided model for their first agreement period