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Concomitant administration of drugs that influence inducers or inhibitors of CYP2C9 is known to affect its efficacy

In a 10-year institutional review for the treatment of chemotherapy for MPNST in NF1, which followed the cases of 1 per 2,500 in 3,300 live births, chemotherapy did not seem to reduce mortality, and its effectiveness should be questioned

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This condition affects women by causing symptoms such as weight gain or obesity, infertility, insulin resistance, high testosterone levels, ovarian cysts, excessive facial hair growth, and scalp hair thinning