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In fact, we evidenced that the nanoprobe could efficiently bind on and then pass through the BBB of mice using an intravital real-time CLSM

MOTS-c modulates the FOXO transcription factors and regulates cellular senescence, the state in which aged or damaged cells stop dividing but refuse to die, instead secreting a cocktail of inflammatory signals known as the senescence-associated secretory phenotype (SASP)

Inside the testes themselves, testosterone concentrations run approximately ten times higher than serum levels

ARTs, including IVF, are further shedding light on the effects smoking has on follicular health

doi: 10.1161/CIR.0000000000001209, 13

Importantly, even the integrity of BBB can vary among PD patients, altering permeability of therapeutic agents and further complicating the development of effective PLGA nanoparticle therapies 145,146