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Stage Standard loading Days Weeks 3-6 Dose 500-1000 mcg daily Notes Continued until target pigment is reached

Long-term use beyond 1.5 years

Proportion Achieving Clinically Significant Weight Loss The proportion of participants achieving clinically significant weight loss thresholds (5%, 10%, and 15% of baseline weight) was higher among engaged participants compared with nonengaged participants

RF energy contracts existing collagen fibers and stimulates further fibroblast activation through controlled thermal stress

J Transl Med 23 , 530 (2025)

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