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Although most of these data were generated in regenerative settings rather than during steady-state aging, they support a model in which aging can reduce the MuSC pool through probabilistic loss or dysfunction of MuSCs (or labeled lineages) without implying deterministic, subset-specific collapse of heterogeneity (Fig

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The precipitated protein was rinsed with 1 ml ice-cold acetone with 0.1% HCl, and centrifuged at 8,500 g for 5 min at 4C

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Autophagy-dependent ferroptosis in infectious disease