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More serious but less common adverse effects observed in trials or associated with this drug class include: Increased heart rate , a class effect seen with GLP-1 receptor agonists [15] [12] Gallbladder disease , including gallstones (cholelithiasis), which has been associated with rapid weight loss and incretin-based therapies more broadly

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2018), the cytotoxin-associated protein A (CagA) encoded within the cagA pathogenicity island (CagPAI) and translocated to eukaryotic cells by type four secretion system (T4SS), and the vacuolating cytotoxin A (VacA)

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PMID 11935176