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Materials and methods: Overnight fasted Sprague-Dawley rats underwent primed, continuous infusions of [1,2- 13 C 2 ]-L-glutamine vis--vis lactate, propionate, acetate infusions

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The product sold by clinics is a synthetic 15-amino-acid peptide manufactured by "solid-phase synthesis", administered under the skin, into the muscle or a joint, or intravenously, often at higher doses for weeks

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ROS exert cellular toxicity by modifying DNA, lipids, and proteins through DNA base oxidation, lipid peroxidation, and protein carbonylation (protein oxidation), respectively 7,8,9