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Growth hormone is the main example

Fluid rushes to the area to flush out the damaged cells and build new, stronger muscle cells and that can be uncomfortable

10.1038/s41580-020-00314-w [DOI] [PMC free article] [PubMed] [Google Scholar] Dimri G, Band H, Band V (2005) Mammary epithelial cell transformation: insights from cell culture and mouse models

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Its relatively small size allows it to interact directly with enzymes rather than acting through peptide receptors