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The expression and enzymatic activity of IDO can be significantly upregulated by pro-inflammatory cytokines such as TNF-, IL-6, and IFN- (47), and contribute to the regulation of the Treg/Th17 balance (48), thereby linking immune activation status closely with kynurenine production, thereby linking immune activation closely with kynurenine production

Oct-Dec 2009;51(4):217-24