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221 Studies specific to dementia and related outcomes have reported that higher longterm exposure to PM 2.5 is associated with worse cognitive decline, 222 , 223 reduced brain volumes, 222 increased dementia severity 224 and increased rates of incident (new onset) dementia

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In the gut, the specific Siglec-8 ligand distribution is less characterized, but colonic mucus and epithelial glycocalyx are rich in sialylated and sulfated glycans that could serve as ligands (189)

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Table 3 shows the characteristics of the GLP-1 receptor agonist-SGLT-2 inhibitor combination users and SGLT-2 inhibitor users after matching

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