The biologic clock: the mitochondria
The model has always allowed you to simulate weight loss and nausea outcomes, but has been expanded to include two new oral treatments, semaglutide and orforglipron, as well as drugs with additional mechanistic components, such as the GLP1-GIP-GLP triple agonist, retatrutide
GLP-1 side effects to monitor for include: Nausea or vomiting Diarrhea or constipation Fatigue Decreased appetite Low blood sugar (hypoglycemia) If any side effects are persistent or concerning to you, contact your prescriber
Metabolomic studies have displayed this altered cellular energetics, but the affected metabolites differ between studies (186, 269, 405407)
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