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(Level I) Aris A

Liraglutide, semaglutide and tirzepatide are incretin-based therapies currently approved by FDA for the management of obesity, while triple GIPR/GCGR/GLP-1R agonist retatrutide (LY3437943), the cagrilintide/semaglutide (CagriSema) 2.4 mg combination, high-dose oral semaglutide, and oral orforglipron are in advanced stages of development

As a result, glucose from the food is not broken down

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The STEP clinical trials demonstrated an average 14.9% reduction in body weight over 68 weeks, with one-third of participants losing over 20% of initial body weight

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