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Decrease in serum insulin level shows improved insulin sensitivity under metabolic stress (Figure 1B)

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Comparison with Other COMT Inhibitors Drug Site of Action Liver Toxicity Notes Entacapone Peripheral only Low Most commonly used Tolcapone Peripheral + CNS High Requires liver monitoring Opicapone Peripheral Low Long-acting, once daily --- 11

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This is an illustrative research schedule, not a prescription