TN, AJS and SEW performed statistical analyses
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GLP-3 might fit into combination strategies by providing complementary metabolic effects not fully achieved by GLP-1 alone, potentially enhancing specific aspects like fat oxidation or metabolic flexibility, possibly allowing lower doses of each peptide with fewer side effects, or addressing metabolic resistance that can develop with single-peptide approaches
While most hepatic enzyme elevations are transient and reversible, rare cases of progressive injury highlight the role of individual susceptibility, such as genetic predispositions or concurrent autoimmune conditions (Sauder et al