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Recent update on siRNA therapeutics

Liposomal, intravenous, or intranasal forms offer higher systemic delivery

And while they're way gentler than retinoids are, they can still cause a rash

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Cycling strategies and break protocols The GHK-Cu discontinuation profile suggesting gradual benefit decline without rebound effects creates opportunity for cycling strategies potentially offering benefits including reduced long-term cost through intermittent rather than continuous product purchase, decreased skin adaptation risk by preventing tolerance to copper peptide stimulation, improved treatment responsiveness when restarting after breaks allowing periodic benefit surges, and psychological flexibility avoiding dependency mindset from continuous indefinite use requirements

The forest plot from this meta-analysis is striking