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The genes encoding for these enzymes, notably MTR and MTRR, may affect the methylation cycle in ways that could affect the detoxification of homocysteine, the methylation of DNA, and the production of antioxidants such as glutathione

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There are also no validated dosing guidelines for DSIP, which compounds the risk: an unvalidated dose paired with a product of unverified identity is a poor foundation for any clinical decision

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