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Keywords: Obesity, Type 2 diabetes, GLP-1RA, Incretin therapy, Pharmacotherapy for obesity, Weight management, GLP1/GIP dual agonists, GLP-1/Glucagon dual agonists, GLP1/GIP/Glucagon triple agonists, Metabolism, Energy expenditure, Insulin secretion Introduction Obesity and type 2 diabetes (T2DM) are two of the most common noncommunicable diseases (NCDs) in the world