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Certain substances can make your blood thinner, meaning it takes longer to clot if a capillary is nicked

In the landmark 68-week STEP-1 trial, adults with overweight or obesity who reached the 2.4 mg maintenance dose lost roughly 15% of their body weight on average a magnitude that had previously belonged to bariatric surgery, not an injection

These differences alter nanoparticle residence time and payload diffusion [524, 525]

Fazirsiran was associated with stable pulmonary function, reduced serum Z-AAT, improved laboratory measures and a safety profile that supports its further clinical development in patients with AATD-LD

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doi: 10.1016/S0140-6736(19)31149-3 16 NorthEJNewmanJD