You've been infected with a tapeworm
J Clin Invest 2005
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Pathogenesis involves antibody-mediated thyroid tissue damage, progressive fibrosis, and impaired synthesis of triiodothyronine (T3) and thyroxine (T4) (Cayres et al
These mediators contribute to central appetite control and neuronal plasticity, while FGF21, especially stimulated by resistance exercise, further modulates hypothalamic circuits and promotes the browning of white adipose tissue, enhancing thermogenesis (45)
1 Despite these constraints, the commercial consequence has been significant: Medicare logged $27.5 billion in gross GLP-1 spending across 21.8 million claims in 2024, entirely under FDA-approved indications other than obesity
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