GLP-1 exerts its effects through several key mechanisms: Glucose-dependent insulin secretion : GLP-1 stimulates pancreatic beta cells to release insulin, but only when blood glucose levels are elevated, reducing the risk of hypoglycaemia Glucagon suppression : It inhibits the release of glucagon from pancreatic alpha cells, thereby reducing hepatic glucose production Delayed gastric emptying : GLP-1 slows the rate at which food leaves the stomach, leading to more gradual glucose absorption and increased satiety Appetite regulation : Acting on brain centres, GLP-1 promotes feelings of fullness and reduces food intake Prescription GLP-1 receptor agonists (such as semaglutide, dulaglutide, and liraglutide) are synthetic analogues designed to mimic and enhance these natural effects
What factors might healthcare providers consider when prescribing GLP-1 agonists for a client with Type 2 diabetes, and how do these factors influence the overall treatment plan
Step 6: Allow dissolution Do not shake
They can be minimized by: Rotating injection sites (abdomen, thigh, upper arm) Allowing the medication to reach room temperature before injecting Using proper injection technique with the correct needle gauge Cleaning the site with alcohol and allowing it to dry Headaches Frequency: Common (reported in 5-15% of users) Severity: Mild to moderate Duration: Hours
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Puzio-Kuter AM
