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A recurrence rate of 32% and a metastates rate ranging from 13% to 44% has been reported, therefore all cases should be considered potentially malignant

This is one reason gentle handling is emphasized

10.1371/journal.pone.0034263 149 SkopelitouK.MuletaA

In contrast, subsequent treatments (PBS + laser (808 nm, 1 W/cm 2 ), PDA, PDA@Pt, PDA@Pt + laser (808 nm, 1 W/cm 2 )) led to a downregulation of P65 expression and a gradual inhibition of the NF-B signaling pathway

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