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Unlike prior reviews, which often present descriptive overviews, this article emphasizes comparative evaluation of design principles, biological mechanisms, and translational hurdles, including biosafety, tumor heterogeneity, and large-scale manufacturability

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COMT also affects estrogen clearance in women connecting the Sexual Health and Women's Hormone pathways but its libido-relevant function is primarily through catecholamine neurotransmitter metabolism in limbic circuits

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