Non-oral HRT (patches, gels, and injections) bypasses the stomach, so an interaction isnt expected
While agonist peptides based on either scaffold are potent in rat obesity models 2,10,11,12,13 , only a transient weight loss effect is observed with sCT in mouse diet-induced obesity (DIO) models 14 , indicating that there may be distinctions in the mode of action of individual dual agonists
Women who are already ovulating more regularly due to weight loss, which itself can restore menstrual regularity in those with prior anovulation, face a compounded fertility increase
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doi: 10.1073/pnas.71.8.2969
This is why we focus so heavily on bioavailability