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Although human epidemiological studies are being conducted to address the effect of repetitive blasts (e.g., with Marines) and a longitudinal study is being carried out with combat veterans and retired athletes (see Stern et al., Appendix C), there is also a need for animal models that replicate repetitive TBI in humans

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This could lead to Vit B12 depletion and transforms SAM into S-adenosyl-homocysteine and then into Hcy, the latter serving as a marker for methylation capacity (Mller and Riederer 2023)