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The accumulation of A leads to the overactivation of microglia and astrocytes, triggering release of pro-inflammatory cytokines, such as IL-1 and TNF-, that sustain chronic neuroinflammation [249]

Faecalibacterium prausnitzii alleviates inflammatory arthritis and regulates IL-17 production, short chain fatty acids, and the intestinal microbial flora in experimental mouse model for rheumatoid arthritis

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Folate supplementation may increase methionine and SAM levels 25 and, as a result, improve methylation

Preclinical studies have suggested that the use of BPC peptide therapy may have significant potential benefits for the recovery process of ligament injuries, joint problems, and also gastrointestinal health, including gastric ulcers and inflammatory bowel disease

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