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PI-PLC has a dual role in pathogenesis

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After washing three times with TBST, membranes were incubated with goat anti-mouse IgG (1:4000 dilution, A0216, Beyotime) to detect the primary antibodies

Hyperphosphorylated tau detaches from microtubules, aggregates, and forms paired helical filaments, leading to the collapse of the neuronal transport system and subsequent neurodegeneration (Han et al