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Cyclooxygenase converts arachidonic acid into leukotrienes and prostaglandins, chemicals that contribute to inflammation and allergic reactions

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The 2.5 mg dose is better called the low-dose starter, because it is the labeled start and now has short direct non-diabetic data behind it. Microdosing has been used for tolerability testing, metabolic-marker support, step-down protocols, and maintenance, not for proven long-term obesity outcomes