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Melanin production and UV protection are not the same thing, and darker-looking skin from an injection offers none of the natural defenses that make a true, gradual tan slightly more protective than pale, unadapted skin

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doi: 10.1016/j.cellimm.2013.09.007 110 WeyandCMGoronzyJJ

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The 12-month trial design enables us to assess senolytic-associated changes before and after treatment during the 3-month active treatment phase, track the reappearance of senescent cells after their removal during the 9-month post-treatment period, and evaluate disease trajectory differences over a one-year period (Figure 3)

FDA drug labeling guidance outlines regulatory expectations for such mechanisms