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The basis for the enhanced toxicity is that chronic ethanol exposure can induce Cyp2E1 enzyme activities and thus enhance NAPQI formation [175]

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doi: 10.1159/000048225 99

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106 Two additional clinical trials are being conducted to gather more data on adverse effects in different situations of liver injury, and a phase 2 trial investigating treatment effects for MASH with fibrosis based on histological assessment is ongoing (NCT05877547)

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