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If you encounter Canadian or cross-border offers for compounded GLP-1s, treat them with significant caution

Probiotics for semaglutide users and products like Pendulum GLP-1 probiotic may help normalize GI function, which in turn can reduce electrolyte losses from diarrhea

Patients with a history of severe gastrointestinal disease, particularly those with inflammatory bowel disease, severe gastroesophageal reflux disease, or history of pancreatitis, require careful evaluation before considering this therapy

The categories that do carry labeled warnings are worth knowing

Distler JH, Hirth A, Kurowska-Stolarska M, Gay RE, Gay S, Distler O

This sustained start may lead to different patterns of downstream signaling and gene expression compared to the pulsatile start that occurs with native IGF-1