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A: Both methods provide systemic distribution

Similarly, in a pancreatic ductal adenocarcinoma subcutaneous mouse model (Pan02 tumor-bearing mice), combining attenuated Toxoplasma of the NRTUA strain with an anti-PD1 antibody significantly enhanced the antitumor activity, induced a strong immunogenic response, with effectively controlling tumor growth

In findings from a phase 2a trial that were presented at the American Diabetes Association Scientific Sessions and simultaneously published in The Lancet , 71% of adults receiving coadministered cagrilintide and semaglutide 2.4 mg, dubbed CagriSema (Novo Nordisk), lost at least 10% of their body weight, and 89% of adults achieved an HbA1c of less than 7% with the combination therapy

This means that they penetrate deeper into the skin

Ismaeil FM, Ahmed SEE, Jabereldar AA, El-Naim AM, Ahmed EEBM